VERIFIED SOLUTION i

MapInfo Pro - How to resize the layout frame without resizing the map contents?


 
  1. Change the frame size in the layout to a smaller size
  2. Double click on the frame and uncheck the 'Fill Frame with Contents' option - screenshot below illustrates this...
User-added image 

This should result in a smaller sized frame which fits tighter around the map contents.
UPDATED:  April 10, 2017